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In animal and early human studies, it has been shown to: Accelerate tendon and ligament healing making it especially relevant for plantar fascia and Achilles injuries
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Contraindications to ospemifene use include 35 undiagnosed abnormal genital bleeding estrogen-dependent neoplasia hypersensitivity to ospemifene active or history of deep vein thrombosis or pulmonary embolism active or history of arterial thromboembolic disease (e.g., stroke, myocardial infarction) Women taking ospemifene should not take estrogen or estrogen agonist/antagonists, fluconazole, or rifampin concomitantly
For that reason, monitoring should track both biological response and protocol execution
They shape how clinicians initiate therapy, how insurers assess coverage, and how patients perceive the purpose of the medication