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Gradually reduce frequency over two to three months if you wish to discontinue
Discontinuation Rates Due to GI Adverse Events Stomach pain severe enough to cause participants to leave clinical trials is the most meaningful measure of GI tolerability
Meanwhile, evidence is mounting of the wider therapeutic benefits of GLP-1 drugs, with clinical trials ongoing for metabolic liver disease, cardiovascular diseases, chronic kidney disease, and neurological disorders, among others
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Changes in the autonomic nervous system also play a role
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