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Metformin use and risk of B12 deficiency increases with the dose and the duration depletion can be seen as early as 3-4 months after starting so it is important to attend for follow up blood tests and talk to your doctor
When your body has insufficient levels of vitamins in the body, your metabolism slows down and you will have a high tendency to gain weight
direct target-binding or target-engagement evidence
Because of this, taking more than the recommended dosage of Vitamin B-12 will neither help nor harm you unless you have an actual problem with deficiency
This can lead to better quality sleep and a more balanced sleep-wake cycle
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