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Evidence from approved GLP-1 receptor agonists provides relevant context, though it is important to note that some interactions are agent-specific rather than class-wide effects
The third receptor glucagon increases energy expenditure (calorie burning at rest) and reduces liver fat
Berberine, a plant alkaloid used in traditional medicine, has gained attention for its metabolic benefits, yet it is fundamentally different from GLP-1 receptor agonists like semaglutide
THCV's interaction with cannabinoid receptors appears to support these processes naturally, potentially offering metabolic benefits without the digestive disruption
Metabolic/bariatric surgery, despite its marked efficacy, remains a last-line option due to its invasiveness and potential for complications (Table 1)
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