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The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program provided the primary evidence base, showing continued efficacy without significant safety concerns emerging over extended use
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Group 3 is the so-called 'leaf group', however, still little is known about the characteristics of this group
But it also reported complete weight regain after two years in: It takes a lot of effort to keep that weight off once you stop taking a GLP-1, says Dr
Other drugs are available that work similarly to semaglutide
Most episodes occurred during the initial weeks of treatment or following dose escalation, with frequency and severity typically decreasing over subsequent weeks
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