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Normally glucagon is known for increasing blood glucose, but when carefully balanced alongside GLP-1 and GIP stimulation it may also: increase energy expenditure stimulate fat metabolism increase calorie burning improve liver fat reduction promote greater weight loss Essentially, GLP-1 and GIP reduce calorie intake whilst glucagon may increase calorie expenditure

59 In MASLD patients with inadequate glycemic control on metformin, sitagliptin (a DPP-4 inhibitor) and liraglutide 1.8 mg daily showed no significant differences in improving LFC assessed by MRI-PDFF, visceral adipose tissue, and weight reduction

Nausea 15-44%, vomiting 5-24%, diarrhea 8-30%, constipation 5-24%

Monitoring : Periodic check-ups with your practitioner ensure that the treatment is working effectively and if any adjustments need to be made

In one study, patients regained about two-thirds of the weight they had lost just one year after stopping semaglutide treatment, and their cardiometabolic risk markers (blood sugar, cholesterol, etc.) reverted toward baseline (source)

Common mistakes include injecting too quickly (causing tissue trauma), reusing needles (which dulls the tip and increases pain), and injecting cold medication (which intensifies discomfort)