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Smotrys, J
Targeting specific molecular pathways in reactive astrocytes presents additional therapeutic opportunities
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While some growth hormone secretagogues also appeared to trigger increased levels of other hormones such as cortisol and ACTH, Ipamorelin and Modified GRF 1-29 peptides appeared to exhibit selectivity towards growth hormones only, suggesting that these peptides may be particular in their functions
Despite these challenges, PDE inhibitors, particularly PDE1B and PDE10A inhibitors, have emerged as promising therapeutic targets due to their ability to modulate the cAMP/PKA/CREB signaling cascade
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