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doi: 10.2337/db14-1051 Gupta T, Kaur M, Shekhawat D, Aggarwal R, Nanda N, Sahni D

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Then a pH change cleaves the linker, freeing the lanifibranor moiety to escape to the nucleus and activate PPARs

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Both medications are not recommended for pregnant women, those trying to conceive, breastfeeding, or patients with a history of pancreatitis and gall bladder issues