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Research shows that tirzepatide does not rely exclusively on neuronal GLP-1 receptors for its anti-inflammatory effects

As the RIPK1-targeted inhibitor of necroptosis, necrostatin-1 could both rescue the ferroptosis and necroptosis of RPE cells via inhibiting RIPK1/RIPK3 activation and lipid ROS accumulation ( 3.5 Neuroprotective agent Acetyl5methoxytryptamine, also known as melatonin (C13H16N2O2), is a hormone that is secreted by the pineal gland in the brain, and shows great potential as a neuroprotective agent ( 4 Challenges for the application of ferroptosis targeting agents 4.1 Approved ferroptosis targeting agents Given the novel role of ferroptosis in the pathogenesis of various retinal diseases, ferroptosis is a promising therapeutic target

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Another study in rodents showed similar results, whilst also highlighted the reversal of steatohepatitis in female mice [59]