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Functionally significant insulin-like growth factor I receptor mutations in centenarians

Normalizes adipocyte size and function

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Metabolic Disorders The recommended dose is 50 mg/kg given as a slow 2 to 3 minute bolus injection or by infusion

256 Therefore, the administration of KD may be a potential approach to enhance the therapeutic efficacy of chemotherapy

Ongoing Supervision Regular follow-ups include lab testing (IGF-1, glucose, metabolic markers), clinical assessment of sleep, energy, body composition, and side effects