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Presented for research literature review only Kato S et al

Skin repair slows with age across several connected systems: collagen genes fire less, capillary supply thins, and repair cells lose coordination

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First-line obesity treatments include lifestyle intervention (e.g., low-calorie diets) and behavioral modification therapies 4,5 since approved obesity medications have limited efficacy and commonly have side effects 6

But the clinical evidence gap is significant: no human trials, no FDA approval, and an unregulated market growing far ahead of the science