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The observed sex dimorphism in inflammatory cytokines was a particularly intriguing and unexpected observation, which beyond serving as a marker of aging status, could be reflective of the relative increase and decrease in neoplasms, documented in male and female mice, respectively

Wu L, Olverling A, Huang Z, Jansson L, Chao H, Gao X, Sjoholm A: GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats

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For a deeper look at why dose escalation creates problems long-term, read our post on why higher GLP-1 doses don't always produce better long-term results