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These risks may include: Nausea and vomiting Diarrhea or constipation Low blood sugar (especially in those with diabetes) Unknown long-term safety concerns due to a lack of research on combined use To date, the FDA has not approved the combination of semaglutide and tirzepatide for any purpose
The narrative surrounding off-brand semaglutide and tirzepatide use is beginning to shift as tirzepatide was removed from the FDAs drug shortage list in December and semaglutide was taken off the list in February
Ma J, Rayner CK, Jones KL, Horowitz M
doi: 10.1038/s41467-023-40982-8, 76 LiuM.LiH.YangR.JiD.XiaX
IV therapy delivers 2-6 times higher doses directly to liver tissue, potentially providing even greater benefits
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