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[13] One Dutch study found that after adjustment for gender and age, there was a statistically significant negative association between the use of metformin and vitamin D status, with those who did not use a vitamin D supplement having levels of vitamin D 14.4 percent lower than controls

However, studies have shown that consistent use over 2-3 months can lead to mild skin brightening effects and may help lighten superficial pigmentation

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Patients with high cholesterol typically require specific lipid-modifying therapy, most commonly statins, as recommended by NICE guidelines (NG238)

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