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As a peptide derived from human gastric juice, it is natively resistant to low pH and proteolytic enzymes

It May Enhance Post-Exercise Recovery It turns out that yerba mate may lend a helping hand after your workouts, too

Phase 2 trial data (published in New England Journal of Medicine, 2023 ): 24.2% average weight loss at 48 weeks with 12 mg dose 22.8% with 8 mg dose Placebo group lost 2.1% Most recent Phase 3 trial data (TRIUMPH-4, December 2025): 28.7% average weight loss at 68 weeks with 12 mg dose 26.4% with 9 mg dose 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% weight loss For context: These are the highest weight loss numbers reported in any clinical trial for a pharmacological obesity treatment

Common adverse effects include nausea, vomiting, diarrhea, and constipation , which are usually mild to moderate and often diminish over time with dose titration

There are several weight loss tablets and injections available, both privately and on the NHS