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Fusobacterium nucleatum, a bacterium closely associated with colorectal cancer, 192,199 can translocate to breast cancer tissues exhibiting high Gal-GalNAc expression through hematogenous spread, primarily via the interaction between Fap2 expressed by Fusobacterium nucleatum and Gal-GalNAc on the surface of breast cancer cells

This improvement in metabolic and reproductive health may offset any theoretical concerns, making semaglutide a net positive for fertility planning when used strategically before conception attempts

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Therefore, we speculate that applying incretin-based medications in PD models can promote insulin secretion, improve peripheral and central insulin resistance, stabilize mitochondrial function, enhance energy metabolism, and exert neuroprotective effects that stabilize dopamine homeostasis (88)