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Retatrutide is a synthetic peptide that mimics gut hormones to regulate appetite and metabolism
Some patients benefit from a lower maintenance dose of semaglutide rather than complete discontinuation, which allows ongoing appetite management at lower cost while preventing the weight-loss plateau effect that can occur with continuous high-dose therapy
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This trade-off is favorable, as joint pain from osteoarthritis is often more limiting and harder to manage than transient muscle soreness
the results are shown in Fig
doi: 10.1111/joim.12255 10
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