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It is commonly prescribed to those with type 2 diabetes
Its the active ingredient found in medications like Zepbound and Mounjaro
In pre-specified analyses for time to first occurrence of MACE, there were 44 MACE-5 (all-cause death, heart attack, stroke, heart failure event, or coronary revascularization ) events observed in participants randomized to retatrutide (pooled 9 mg and 12 mg) and 52 events observed in those randomized to placebo, resulting in a hazard ratio of 0.82 (95.0% CI: 0.55 to 1.22)
The 4mg dose, which still produced significant weight loss (15.2%), had nausea rates of just 18% and discontinuation rates of 5.7%
Separate from hormone signaling, other researchers are studying gut bacteria as another route to sustained weight management
Common reasons include missing documentation or failure to meet eligibility criteria
