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One of the primary functions of vitamin D3 is to regulate the levels of calcium and phosphate in the body

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Therefore, mechanical and gravitational forces can alter a number of processes, including gene expression, signalling, adhesion/migration properties, proliferation (91), differentiation (92) and apoptosis (9395), as well as the way that cells organize themselves into three-dimensional (3-D) structures (constructs, tissues, and organs) (96)

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Animal pharmacokinetic work has also shown species-dependent absorption after intramuscular dosing, which complicates extrapolation to humans