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The same logic that makes MOTS-C work with Retatrutide applies to semaglutide and tirzepatide, just to a lesser degree
B6 deficiency can cause irritability, fatigue, and difficulty concentrating, so maintaining adequate levels is important during treatment
Siegel et al
obesity + T2D, highest dose: Retatrutide: 28.3% 20.8% Semaglutide 7.2 mg: 20.7% 14.1% Orforglipron: 12.4% 10.5% Placebo-adjusted, retatrutide 12 mg delivered about two-thirds of the effect in type 2 diabetes that it delivered in the non-diabetic TRIUMPH-1 cohort 16.8 points versus 26.1 points
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Do not adjust insulin just to qualify for donation unless your own diabetes care team gives specific instructions
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