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An acute glucose-lowering effect of DPP-4 inhibition in a rodent model of T2DM (the obese Zucker rat) was demonstrated when it was shown that a different inhibitor (isoleucine thiazolidide) reduced plasma DPP-4 activity and was associated with a larger insulin response and improved glucose tolerance after an oral glucose load (when endogenous GLP-1 secretion would be stimulated) (26)
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[4] [5] However, these studies predominantly involved populations with pre-diabetes or metabolic syndrome, and results may not generalise to individuals seeking weight loss without metabolic dysfunction
Skeletal-muscle growth and protein turnover
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