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I have proposed criteria for second-generation obesity medications based on health benefits and the potential to transform obesity care, which include mean placebo-subtracted weight loss of more than 10% and weight loss of 15% or more in conjunction with lifestyle intervention in randomized trials

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They increase anti-inflammatory IL-10 levels in the heart 9

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On this basis, we further investigated the impact of c-Myc suppression on GGCT expression, and the results showed a significant reduction in GGCT protein levels (Fig