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Diamine Oxidase Supplementation Improves Symptoms in Patients with Histamine Intolerance. Food Science and Biotechnology, vol

doi: 10.3389/fendo.2026.1694550 Received 28 August 2025 Revised 03 January 2026 Accepted 06 January 2026 Published 27 January 2026 Volume 17 - 2026 Edited by Hossein Neamatzadeh, Shahid Sadoughi University of Medical Sciences and Health Services, Iran Reviewed by Sedigheh Ekraminasab, Shahid Sadoughi University of Medical Sciences and Health Services, Iran Walter Moos, University of California, San Francisco, United States Updates Copyright 2026 Li, Mao, Zhang and Xu

Conclusion In this study, serum acetylcarnitine was significantly lower in the MDD group, regardless of exposure to drug treatment, which differed significantly between the MDD group and the control and remission groups

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With age or factors such as poor diet, strenuous exercise, being overweight and certain health conditions, the amount of glutathione in our body decreases

This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)