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The two are mechanistically separate compounds with independent literatures, and each is studied on its own terms rather than as a validated combination

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& Zinner, M

Strong acids, retinoids, and vitamin C may interact with or destabilize GHK-Cu when applied simultaneously

Mechanistically, it acts as a non-selective agonist of the melanocortin receptors, with reported activity at MC1R, MC3R, and MC4R

Dihexa was administered to the APP/PS1 mice intraperitoneally from 6 to 9 months of age and 0.9% saline was administered to the wild type group once per day over a three month time period