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Prospective studies should incorporate clinically meaningful endpoints rather than surrogate mechanistic outcomes

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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Once reconstituted, the stability is the same regardless of whether you mixed a 10 mg vial or a 60 mg vial