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DSIP (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide originally isolated from rabbit cerebral venous blood

In MCAS, mast cellswhich line the blood vessels, nerves, and mucosal tissuesbecome hyper-responsive, inappropriately releasing massive amounts of histamine, cytokines, and other inflammatory mediators in response to minor environmental or internal triggers

it is primarily eliminated via bile rather than through kidneys

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This network dysregulation manifests as a key phenotype of "inadequate energy supply and loss of metabolic flexibility", leading to compromised oocyte meiotic maturation and support from granulosa cells

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