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This creates a harder-to-break plateau, not a faster path through it

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in patients with type 2 diabetes mellitus, the incretin effect is responsible for less than 20% of the insulin response to an oral glucose load, whereas it accounts for roughly two-thirds of the response

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However, in patients over 65, those with a history of prediabetes/diabetes, anyone with a cardiovascular disease, and anyone who has been severely overweight should expect to stay on medication forever due to the significant reduction in disability and death

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