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The ratio of the signal measured at 665 nm on signal measured at 620 nm is used to determine the cAMP concentration

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Tissue macrophages are established during embryonic development while circulating macrophages originate from monocytes coursing through the blood ( Macrophages also exist in a resting or activated state, with activated macrophages further divided into M1 (so-called classical or inflammatory macrophages) and M2 (aka alternative or reparative) subtypes

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