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While GLP-1s clearly are effective for weight loss, experts may be concerned if their patients do not make other lifestyle changes, for example, changing their diet or being more active
Digestive Side Effects Nausea, vomiting, and diarrhea are common with tirzepatide, especially during dose changes
2015 examined obese male mice on a high-fat diet and reported that while the HFD mice had lower serum testosterone (which exenatide treatment did not fully restore), the GLP-1 RAtreated mice did show improved sperm motility, enhanced sperm mitochondrial activity, and reduced sperm DNA fragmentation compared to untreated obese controls
The development of semaglutide nasal spray is an exciting advancement in GLP-1 therapy and highlights the importance of innovative drug delivery for better patient care
I vividly remember debating the GLP-1 market size with sell-side analysts around this time, and several contested the TAM was $30-50B, even though my conservative napkin math pointed to $100B-$300B3
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