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5.1.2 Enhancement of gut and bloodbrain barrier integrity Recent studies have shown that a vicious cycle of inflammation and oxidative stress is created at the renal level by the influx of uremic toxins and urea into the gastrointestinal lumen via the enterohepatic cycle, which exerts a selective pressure that encourages the excessive growth of bacterial species that produce urease, uricase, indole, and p-cresol-forming enzymes with a reduction in SCFAs-producing species (Vaziri et al., 2013

The Microdosing plan is designed for individuals with a BMI between 20 and 25

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Although alcohol is not contraindicated, it is advisable to limit consumption during treatment as both alcohol and isotretinoin can raise blood triglyceride levels