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Hamid, H

increased levels of proinflammatory mediators and inflammatory potential

82 ZaffagniniM.BedhommeM.MarchandC

As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (4, 6, 11, 1618, 20, 58) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (61, 62)

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Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance