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Nicholls SJ, Bhatt DL, Buse JB et al (2024) Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics

Participants were randomly assigned to receive a once-weekly injection of 2.4 milligrams (mg) of Wegovy or placebo, alongside lifestyle counseling, over a 72-week period (nearly a year and a half)

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Intraperitoneal GLP-1 was shown to lower plasma glucose in GLP-1R knockdown mice without increasing insulin secretion, whereas intravenous GLP-1 did not affect glucose or insulin levels

Week five through six: Move to daily application if every-other-day causes no issues

doi: 10.1002/jcp.27075 120