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Description

Week 3-12: Increase to 100-150 mg daily if well-tolerated

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When total B12 levels are difficult to interpret, measurement of holotranscobalamin (active B12), methylmalonic acid (MMA) , or homocysteine can provide a clearer picture of functional B12 status, though availability and interpretation vary (for example, MMA rises in renal impairment)

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Clinical trials have found that the greatest improvement in haemoglobin A1c occurs within the first 24 weeks of treatment, after which levels stabilise

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