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However, these studies have inherent limitations, primarily stemming from their controlled duration and predefined patient criteria [Reference Blackman, Foster, Zammit, Rosenberg, Aronne and Wadden22Reference Wadden, Hollander, Klein, Niswender, Woo and Hale26]
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These medicines, which work by mimicking the actions of gut hormones released after eating, including one called GLP-1, have been the first diet drugs in history that are both effective leading to 15 to 20 per cent weight loss on average and generally safe
