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Longer term For longer protocols, review metabolic, kidney, liver, and cardiovascular trends every 3-6 months with a clinician

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HCPs should explain to caregivers that maintaining treatment adherence is critical to improving growth for children with SPIGFD, with one study demonstrating that rhIGF-1 resulted in an overall height gain of 13.4 cm more than expected without treatment for SPIGFD patients, with 10.0 years of follow-up (n = 21) [62]

Pfizer plans to conduct dose-optimization studies in the second half of 2024, assessing multiple doses of the preferred extended-release formulation to guide registration-supporting studies

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