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Research suggests that the dual receptor action may make this class of drugs more effective at promoting weight loss than other GLP-1s

Abdullah M, Jamil RT, FN A

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But the FDA has never approved phentermine for long-term continuous use, and the data supporting extended protocols is thin

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Since then, a number of triple agonists have entered clinical development, with one in phase three clinical studies but have yet to reach the market (Capozzi, DiMarchi, Tschp)