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Together, these findings identify the melatonin-NRF2-glutathione axis as a metabolic checkpoint regulating innate type 2 immunity and suggest that therapeutic targeting of redox metabolism may represent a strategy for modulating airway inflammation in allergic asthma

Mutases catalyze the transfer of functional groups within a molecule

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Protein purity was assessed by SDS-PAGE, and their concentrations and 260/280 nm absorbance ratios were determined using a NanoDrop spectrophotometer (Thermo Scientific)