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Applicable Across Sexes: While FDA approval is specific to women, clinical and anecdotal evidence suggest efficacy in men, particularly those inadequately responsive to PDE5 inhibitors

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118 Aspirins role in regulating specialized proresolving mediators (SPMs) in colonic tissues has been emphasized, with aspirin downregulating PD-1 expression in macrophages and CD8+ T cells, thus improving immune responses against inflammation-associated CRC

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