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AOD9604 free base and AOD9604 acetate should not be treated as analytically identical bulk drug substances
High oral bioavailability Caco-2 cell assays showed excellent passive and active membrane transport with no detectable efflux (Neelakantan et al., 2018)
This direct approach ensures that the vitamin is absorbed efficiently, especially in individuals who may have difficulty absorbing B12 through the digestive tract due to certain health conditions
Each batch is analytically tested to ensure quality, consistency, and high purity standards
Where results are borderline, measurement of methylmalonic acid (MMA) or holotranscobalamin (active B12) may help clarify the picture, as recommended in NICE CKS guidance on B12 and folate deficiency anaemia
