This stepwise approach allows monitoring of tolerability, gastrointestinal adaptation, and metabolic response
MORE: New Jersey sues Amazon for classifying its Flex delivery drivers as contractors The FDA phased out allowing pharmacies to compound GLP-1s after it declared an end to the drug shortages for Mounjaro and Zepbound in October 2024 and for Ozempic in February of this year
Taking two doses close together concentrates the GI-slowing effects and dramatically increases the risk of nausea, vomiting, and other side effects
As of 2025, retatrutide has not received marketing authorisation from the MHRA or EMA and is not available as a licensed treatment in the UK through the NHS or via private prescribing
Since then, Al-Aly said use of GLP-1 medications has exploded
The risk with topical use is relatively low since systemic absorption is limited