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Previous results indicate that TNC is downregulated by GLP-1RA treatment and correlates with incident CVD 43 , suggesting that TNC may act as a mediator, with downregulation contributing to the cardiovascular-protective effects of GLP-1RAs
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GIP perhaps makes a greater contribution to the physiological insulin response to meals than GLP-1, but therapeutic development to date has focused on GLP-1, as the insulinotropic effect of GIP is markedly attenuated in Type 2 diabetes (T2D)
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