doi: 10.3389/fmicb.2023.1160551 164 YoshimuraK.MiyaoK.GaberA.TakedaT.KanaboshiH.MiyasakaH.et al
This made semaglutide the first GLP-1 RA approved specifically for kidney disease protection, paralleling the role of SGLT2 inhibitors in renal care
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Microscopic Findings Increased melanin in basal cell layer Increased melanin production by normal numbers of melanocytes Melanin incontinence Diagnosis History of chronic, heavy smoking Biopsy Clinical appearance Differential Diagnosis Physiologic pigmentation Addisons disease Medication-related pigmentation (drug-induced pigmentation by chloroquine, clofazimine, mepacrine, chlorpromazine, quinidine, or zidovudine) Malignant melanoma Treatment None Reversible, if smoking is discontinued Prognosis Good, with smoking cessation Cafe-au-lait macules Caf-au-lait macules are discrete melanin-pigmented patches of skin that have irregular margins and a brown coloration
