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Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1alpha signaling pathways

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However, in the PCA of the MD holo structure, the weak points in the graphs appear in the first 3 components for replicates 1 and 2, but they appear in the first 2 components for replicate 3 (S3 Fig)

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While preclinical models have yielded valuable insights into microglial heterogeneity, many markers defined in rodent systems [e.g., arginase 1 (Arg1) or rodent-specific chitinase-like protein (Ym1)] have limited expression or different regulation in human microglia