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It is expected that the approval process will be completed in other countries over the coming years

Garg notes

If GLP-1 analog drugs are being submitted as biosimilars, they also require a comparability assessment with the reference drug, including threshold evaluations and examination of parameters such as drug tolerance

The limits are just as clear

While nausea typically resolved over time, diarrhea (observed in 5% of our cohort) tended to persist when present, though it was manageable in most cases with antidiarrheal agents

Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-beta agonist