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The study plans to compare whether reducing the dose to 5 mg or continuing the higher-tolerated dose (10 mg or 15 mg) better helps people maintain their weight loss
Patients are no longer satisfied to simply extend their lifespans
Losing 20-28% of body weight reshapes your entire hormonal landscape
The dominant hypothesis is that retatrutide not only reduces appetite but also controls energy expenditure and overall fat metabolism
Gonzalez JS, Krause-Steinrauf H, Bebu I, Crespo-Ramos G, Hoogendoorn CJ, Naik AD, et al
Why Hormonal and Metabolic Changes Disrupt Periods Rapid weight loss can suppress GnRH secretion from the hypothalamus, reducing LH and FSH and potentially halting ovulation
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