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In rodent models, acute activation of GLP-1-producing neurons has been shown to trigger stress-like and anxiety-like behavior

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According to Chabory et al., an imbalance in antioxidant activity produced by reduced GPx expression leads to oxidative damage to proteins and fatty acids, which produces neurotoxic damage [108]

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Beyond weight loss, Phase 2 data demonstrated improvements in HbA1c , fasting glucose , triglycerides , blood pressure , and waist circumference all clinically relevant markers in the context of cardiovascular and metabolic risk

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