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Weeks 1 to 4 The gut symptoms are usually at their worst while the dose climbs, then ease (Moiz 2025)

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In addition, fatigue and brain fog side effects sometimes reported with GLP-1s may be worsened in people with untreated thyroid dysfunction, making it harder to tolerate treatment

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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia