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The cryosurvival rate was determined by dividing the post-thawing total motile percentage by the pre-freezing total motile percentage and multiplying the result by 100 (Saleh et al., 2018)
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Nevertheless, our cases represent real life multidrug poisonings with possible non-identified co-ingested drugs based on the routine screening, risk of drug-drug interactions and no modifications in management with time
The decline in the activity of mitochondrial and peroxisomal isoforms points toward the fungus-promoted precocious senescence that led to the disease development (Kuzniak and Skodowska, 2005)
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Note that the intracellular concentrations of Hcy, SAM, SAH, and Met all change in the same direction as seen clinically
