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Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts

The folate cycle is crucial for its role in the synthesis of S-adenosylmethionine (SAM) and the metabolism of vitamin B12 (2022, 25, 30, 66)

306 , F1381F1390 (2014)

Typically used with TB-500 during the first 4 to 6 weeks

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Clinical trial number Not applicable