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In about 70% of cases, CSS is associated with a balanced chromosomal translocation t(12;22)(q13;q12) which fuses EWSR1 on chromosome 22 with ATF1 on chromosome 12
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Following a median follow-up of 2.1 years, the risk of suffering a major cardiovascular adverse event (death, nonfatal AMI, nonfatal stroke or hospitalization for unstable angina) was similar in both the lixisenatide and the placebo arms (HR 1.02
doi: 10.3390/ijms21165804 95 MelchiorriDReiterRJAttiaAMHaraMBurgosANisticoG
The receptor reduces ghrelin: hormones that make you feel hungry and increases the release of GLP-1
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